Pancreatin (Pancreatin systemic) is a digestive enzyme supplement that contains a mixture of several different types of enzymes. These enzymes are normally produced in the pancreas. Pancreatin has a primary function of helping to breakdown food and convert it into energy. The supplement is comprised of a commercial mixture of amylase (to digest starch), protease (to digest protein) and lipase (to digest fat).

Pancreatin can be derived from both plant or animal sources. The primary enzymes that comprise pancreatin include amylase, lipase, and protease. Pancreatin or pancreatic enzymes are usually made from cows or pigs, but can be derived from plant sources as well.